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KMID : 0903520060490030221
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Journal of the Korean Society of Agricultural Chemistry and Biotechnology
2006 Volume.49 No. 3 p.221 ~ p.226
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Screening of Medicinal Plants for Development of Functional Food Ingredients with Anti-Obesity
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Kim Young-Jin
Kim Bo-Hye
Lee Sun-Yi
Kim Min-Soo
Park Chan-Sun
Rhee Moon-Soo
Lee Kang-Hyun
Kim Dong-Sup
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Abstract
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In order to search anti-obesity agents, the methanol extracts of 155 herbal medicines were screened using with pancreatic lipase, which is involved in conversion of triglycerol to fatty acid. Among the tested medicinal plants, methanol extracts of Amsonia elliptica, Arecae pericarpium, Biota orientalis, Cinnamomum cassia, Curcuma aromatia, Elsholtzia ciliate, Glycyrrhiza uralensis, Mucunae Caulis, Rhus javanica, and Rubus coreanus showed potent inhibition at final concentration of 200 μg/ml on pancreatic lipase activity. All of them were extracted into chloroform fraction. The relative inhibitory activities against pancreatic lipase by orlistat, the chloroform fraction of Arecae pericarpium and Cinnamomum cassia were 89, 80 and 80%, respectively. These results demonstrated that the screened medicinal plants could be develop as the effective lipase inhibitors in preventing and ameliorating obesity of human beings.
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KEYWORD
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Pancreatic lipase inhibitor, medicinal herbs, obesity, modulating agent
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